Futurology

Alzheimer's reversed in mice, stage 1 human trials funded

Alzheimer's reversed in mice, stage 1 human trials funded
Alzheimer's reversed in mice, stage 1 human trials funded

Heads up on these threads: Alzheimers of all diseases has a history of testing very well in mice and then not passing human trials.

This needs to be emphasized more.

Most, if not all, pharmaceuticals have cut research funding towards their curative therapies for Alzheimer’s disease following the failure of multiple antibody drug trials that tested well in mice but failed in humans.

We remain hopeful - but a large issue is that many of these mouse models are genetically engineered to have an over abundance of human amyloid beta or tau - which is not the same as a human naturally progressing through Alzheimer’s disease. A limitation may be that we just simply aren’t looking at the whole picture and/or are funneling our attention to a small part of the equation.

Here’s the thing i love so much about science. Everyday is a step closer to improving our quality of life, and also an indication to humanity’s boundless growth with regards to science and what we can do.

This is often a difficulty for neuroscience (neurodegeneration studying scientist checking in). The field often encourages use of more “pragmatic” models as opposed to direct translational models. For example, a mouse with an inserted mutant Huntingtin segment exon 1, as opposed to the full length mutant huntingtin. The mice die faster in many cases (good for cost/construe-ably more drastic results), and more importantly, inserting a massive gene into a model system with traditional techniques is... difficult.

As techniques refine, however, this may be abrogated in time.

Cement is the most widely used man-made material in existence, second only to water as the most-consumed resource on the planet, and source of about 8% of the world's CO2 emissions. A start-up is now using trillions of bacteria to grow bio-concrete bricks, similar to the process that creates coral.

Cement is the most widely used man-made material in existence, second only to water as the most-c...

Won't those bacteria also produce co2? They have to have a gaseous byproduct.

Definitely will be waiting on the impact studies. Would the byproducts of this method be less than the resource cost of producing concrete traditionally? Hard to say, though my gut reaction is that it probably depends on if people follow the best practices that will be put forward for the process.

If we’re able to grow bricks, why not grow entire buildings? Set up a form for it to grow in, feed it, and poof, terrifying organic shapes straight out of science fiction.

I'm waiting for the material study.

I don't care how small the impact of your material is. If I can't build a bridge/skyscraper out of it it isn't getting used.

CRISPR dna "cutting" may destroy herpes virus within infected people

CRISPR dna "cutting" may destroy herpes virus within infected people
CRISPR dna "cutting" may destroy herpes virus within infected people

Sign me up (after proven safe). I've had cold sore outbreaks since I was a little kid. Painful and it always made me want to hide my face.

Ask your doctor for Valtrex. As soon as you see it coming on it’ll stop it. It’s used mainly for down there but it also helps with the mouth ones and if you get shingles.

"CRISPR may X" needs to be automatically deleted from this sub.

This is a garbage PloS Pathogens paper (that you have to click through 2 articles to actually find) that's only being posted here because some popsci writer wanted to catch eyes with "CRISPR" in the title.

Edit: I'm getting a ton of PMs trying to educate this published PhD Immunologist on how science works.. lol

CRISPR may automatically delete things from this sub.

Right to end life on Earth: Can corporations that spread climate change denialism be held liable? If a corporation’s propaganda destroys the world, doesn’t that conflict with our right to live?

Right to end life on Earth: Can corporations that spread climate change denialism be held liable?...

Did any of the medical professionals who took money from the tobacco industry in exchange for saying tobacco was harmless go to prison? No, they didn't.

Did anyone from Monsanto go to prison for lying about the health effects of Agent Orange? No, they didn't.

Same thing will happen here.

EDIT:

Okay, did not expect this to be blow the fuck up. I answered a lot of the responses, but not all. Some of them didn't seem to require a response beyond an upvote, and others were so incredibly stupid that I knew it would it be a waste of my time to respond. Still others require further research on my part before I can give a good answer.

Several people have made the claim that Monsanto was forced by the US government to make Agent Orange and I would like to know more about this because how the fuck do you threaten to imprison someone for not making weapons? In a free society, I mean. If anyone can toss a link or a reference I'd appreciate it.

I’m not a lawyer, but it might not be possible to sue someone when the world is dead.

Depends how reliant on corporations the worlds population is when it comes time to assign liability. Corporations get away with so much shit now because those in 'power' know that we need them. They own the world, and they think they can treat it how they like.

I'd like to think things would be different this time since neither of those things threatened the entire human race with extinction. I doubt it, but I'd like to think it.

Image topped coffee maker

The answer to the question: what does a $10 cup of coffee look like?🤔

I'm actually surprised by the coffee image resolution

Back in the 1950s people thought that by now we'd have flying cars and robot maids.

Instead we get coffee selfies.

I'm starting to feel like we went wrong at some point in the past few decades.

This is not for people who don't have time and money

Luxembourg to become first country to make all public transport free

Luxembourg to become first country to make all public transport free

Is it only me? I think public transport should always be free for citizens who pay taxes.

https://www.youtube.com/watch?v=4YIW-kQSYzg

in Naples it's about 30 years that people use public transport for free.

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Agree, but it should just be everybody. Fare collection systems are incredibly expensive. If the majority of your ridership is already fare free, it's more cost effective to never buy the equipment or pay for enforcement.

But then poor people might be able to afford more stuff, we cant have that

Man Postpones Retirement to Save Reefs After He Accidentally Discovers How to Make Coral Grow 40 Times Faster

Man Postpones Retirement to Save Reefs After He Accidentally Discovers How to Make Coral Grow 40 Times Faster
Man Postpones Retirement to Save Reefs After He Accidentally Discovers How to Make Coral Grow 40 ...

Clickbait title.

The method he discovered is very old. Fragging involves taking a coral and dividing into smaller pieces that then all grow on their own plugs.

Every hobbyist and pro in reefing does this already

https://www.youtube.com/watch?v=_0F5cQfke64

Here's him talking for AARP last year about this process. The article in OP makes it seem like he just discovered this process, but he could be responsible for some of the initial breakthroughs in fragging.

It certainly seems that Dr. Vaughan's contributions to micro-fragmenting aren't trivial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614846/

So many of the practices of these "hobby reefers" could still be coming from Vaughan's work, which dates back at least several years.

Good find on the paper but you've got it backwards. Hobbyists have been fragging corals for growth for decades. He borrowed from existing methods and simply formalized the results with an experiment and a publication. Don't get me wrong, I love seeing scientific publications that back up anecdotal experiences in the hobby, but he certainly didn't contribute any novel ideas with this.

I was expecting some fancy process, or special chemical found by accident... nope, just break them all into little pieces and they'll bounce back fine and in a hurry

Supermarket ban sees '80% drop' in plastic bag consumption nationwide in Australia

Supermarket ban sees '80% drop' in plastic bag consumption nationwide in Australia

The unexpected negative side effect is that several of my friends have just switched to using the reusable plastic bags like they used to use single-use plastic bags which has resulted in an overall increase in their plastic consumption since the 'reusable' bags are somewhat sturdier and more plastic goes into their creation.

They never seem to remember to bring their old bags back for reuse and they use them as bin liners, just like they did with the single-use bags...

I read that you need something like 37 or so uses out of a reusable one to actually make it worth the switch. Smaller towns in aus (looking at you IGA Exmouth) have a system where you can borrow one and just bring one in next time.

But also includes potato sacks etc so people don't have to purchase or use a reusable bag they just use the supermarkets waste from the potatoes.

The point isn’t just that it takes 37 uses of the bag (which by the way, properly used for a lot of shopping, not just woolies, means it’s worth it after maybe 2-3 months if you have a medium family).

It’s stopping plastic from entering the system altogether. And this is one of the many steps, including QLDs upcoming ban on single use plastics, which will continue to help. It’s change that can’t happen over night. It’s a one step at a time thing

I never could get in the habit of a reusable bag till I got this type that Ikea sells. https://m.ikea.com/us/en/catalog/products/art/20330491/

Cannabidiol induces a rapid and long-lasting antidepressant effect in rodent model of depression - A substance found in cannabis may be a faster-acting antidepressant than conventional medications, finds a new study in the journal Molecular Neurobiology.

Cannabidiol induces a rapid and long-lasting antidepressant effect in rodent model of depression - A substance found in cannabis may be a faster-acting antidepressant than conventional medications, finds a new study in the journal Molecular Neurobiology.
Cannabidiol induces a rapid and long-lasting antidepressant effect in rodent model of depression ...

As someone with depression and anxiety I can anecdotally confirm the effects of this. I took CBD oil for months and all hints of anxiety and depression vanished. Motivation came back and things didn't always seem so doom and gloom. I'm currently looking for a new job and abstaining from all cannabinoids of any kind has made my anxiety, depression, and sleeplessness all come back in a massive way.

I've been using the 500mg https://naturearc.com/product/premium-hemp-oil/#3 its a spray, pretty tasty . Depression and anxiety have been helped but via a change of lifestyle as well as cbd, started going to the gym etc which really helps you feel good

What dose were you taking? I’m taking 50mg daily but haven’t noticed it helping my depression or anxiety at all.

Has helped tremendously with sleep and pain relief though.

Yo, depressed peeps out there, keep an eye on what this fellow is saying. The weed isn't going to solve the problem. But it can reveal the solution. The weed can make vigorous exercise tolerable and even enjoyable.

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But I am nearly certain that it is the exercise that is improving peoples' biochemistry in a far broader way than merely mucking around with the hydrocannabinoid system. The reefer is merely allowing for the subject to overcome a pain and motivation threshold, is my argument.

Try one of these subthreads